Determination of serum cardiac biomarkers and plasma D-dimer levelsin anemic sheep with babesiosis

Authors : Özlem Orunç KILINÇ, Yaşar GÖZ, Nazmi YÜKSEK, Yildiray BAŞBUĞAN, Ali Bilgin YILMAZ, Ahmet Duran ATAŞ

Pages : 606-610

View : 18 | Download : 8

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :In this study, the cardiac effects of anemia and venous thromboembolism insert ignore into journalissuearticles values(VTE);, reportedly caused by the hemolyzed erythrocytes occurring in sheep with babesiosis, were investigated using cardiac markers and D-dimer insert ignore into journalissuearticles values(DD);. The study included 34 sheep: 24 infected Akkaraman sheep insert ignore into journalissuearticles values(1-3 years old, diagnosed with babesiosis based on clinical and laboratory findings); and a control group of 10 noninfected healthy sheep of the same breed and age. Hematocrit insert ignore into journalissuearticles values(Hct); levels were measured in blood obtained from both groups. Cardiac troponin I insert ignore into journalissuearticles values(cTnI);, creatine kinase-MB insert ignore into journalissuearticles values(CK-MB);, and aspartate aminotransferase insert ignore into journalissuearticles values(AST); levels were measured in serum samples. In addition, the levels of DD were also measured in plasma samples. Sheep with babesiosis were subsequently divided into 3 subgroups according to their Hct levels, which ranged from 13.2% to 16.3% in the first group insert ignore into journalissuearticles values(n = 8);, 20.1% to 25.6% in the second group insert ignore into journalissuearticles values(n = 8);, and 27.4% to 30.3% in the third group insert ignore into journalissuearticles values(n = 8);. Evaluations of the measurements of cTnI, CK-MB, and AST levels indicated statistically significant differences between infected and healthy sheep. Statistically significant differences were not found for DD levels between the 2 groups.
Keywords : Babesia, cardiac biomarkers, D dimer, hematocrit, sheep