An investigation of antibacterial effects of steroids

Authors : Abdullah DOĞAN, Salih OTLU, Özgür ÇELEBİ, Pınar AKSU KILIÇLE, Aliye GÜLMEZ SAĞLAM, Ali Nazmi Can DOĞAN, Neslihan MUTLU

Pages : 302-305

View : 22 | Download : 8

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :  In this study, the effects of steroid substances such as corticosterone, progesterone, estrone, beta-sitosterol, and stigmasterol on some bacteria were investigated. In the research, standard strains of the gram-positive bacteria Bacillus subtilis insert ignore into journalissuearticles values(lab isolate); and Staphylococcus aureus insert ignore into journalissuearticles values(ATCC 6538); and the gram-negative bacteria Escherichia coli insert ignore into journalissuearticles values(ATCC 25922);, Pasteurella multocida insert ignore into journalissuearticles values(ATCC 12945);, and Pseudomonas aeruginosa insert ignore into journalissuearticles values(ATCC 9027); were used. A modified broth dilution method was applied for determining the minimal inhibitory concentration insert ignore into journalissuearticles values(MIC); of the steroids. Mueller Hinton broth insert ignore into journalissuearticles values(Becton Dickinson, 211443); was used to prepare dilutions and as a medium. At the end of the study, the MIC of corticosterone for P. multocida and the MIC of beta-sitosterol for S. aureus were both determined as 32 μg/mL. However, other steroids showed no effects on the bacteria. These steroids did not appear to have widespread antibacterial properties.
Keywords : Corticosterone, progesterone, estrone, beta sitosterol, stigmasterol, antibacterial