Polymorphisms of exon 10 in the BPI gene and its association analysis with some reproductive traits and partial immune indexes in Meishan pigs

Authors : Huan QU, Zongyou WEI, LAN YE, SHENGLONG WU, WENBIN BAO

Pages : 127-133

View : 21 | Download : 5

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :This study was conducted to detect polymorphisms of BPI gene exon 10 by PCR-RFLP in Meishan pigs and their associations with some important cytokine levels insert ignore into journalissuearticles values(IL-1ß, IL-4, IL-6, IL-8, IL-10, TGF-1ß, IFN-γ, TNF-α); and reproductive traits insert ignore into journalissuearticles values(total number born insert ignore into journalissuearticles values(TNB);, number born alive insert ignore into journalissuearticles values(NBA);, birth litter weight insert ignore into journalissuearticles values(BLW);, and weaning litter weight insert ignore into journalissuearticles values(WLW););, with the aim of identifying effective genetic markers for molecular breeding. The results revealed three genotypes, including AA, AB, and BB, with the trend of AA > BB > AB in reproductive traits. Pigs with the AA genotype were significantly higher than the AB genotype in TNB and IFN-γ insert ignore into journalissuearticles values(P < 0.05);, and extremely significantly higher in NBA and WLW insert ignore into journalissuearticles values(P < 0.01);. Moreover, TGF-1ß and TNF-α levels were significantly higher in the AA genotype than the BB genotype insert ignore into journalissuearticles values(P < 0.05);. However, there were no significant differences among the three genotypes in the levels of other cytokines insert ignore into journalissuearticles values(P > 0.05);. Comprehensive analysis indicated that the polymorphisms of exon 10 in the BPI gene have significant genetic effects on some reproductive traits and cytokines in Meishan pigs, for which the AA genotype was demonstrated to be the favorable genotype, which could be used as potential genetic markers for in-depth research and examination.
Keywords : Pig, BPI gene, reproductive traits, immune indexes