In vivo biocompatibility and fracture healing of hydroxyapatite-hexagonal boron nitridechitosan- collagen biocomposite coating in rats

Authors : Mehmet Zeki Yılmaz DEVECİ, Ramazan GÖNENCİ, İbrahim CANPOLAT, Özgür KANAT

Pages : 76-88

View : 18 | Download : 9

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The biocompatibility of orthopaedic implants and their effects on fracture healing have key roles for success. In this study, it was aimed to investigate the effects of a novel biocomposite consisting of hydroxyapatite insert ignore into journalissuearticles values(HA);, hexagonal boron nitride insert ignore into journalissuearticles values(h-BN);, chitosan insert ignore into journalissuearticles values(Cs);, and type 1 collagen insert ignore into journalissuearticles values(Ct1); on biocompatibility and fracture healing in rats. A total of 60 adult male Wistar rats weighing 300?500 g were used in the study. The rats were randomly divided into 2 groups named A insert ignore into journalissuearticles values(uncoated/control); and B insert ignore into journalissuearticles values(biocomposite coated);. Biocomposite insert ignore into journalissuearticles values(HA/h-BN/Cs/Ct1); coated and uncoated stainless-steel implants were used as intramedullary pins. Groups A and B were divided into subgroups of A1 and B1 insert ignore into journalissuearticles values(15th day);, A2 and B2 insert ignore into journalissuearticles values(30th day);, A3 and B3 insert ignore into journalissuearticles values(45th day); according to the date of euthanasia. Clinical, radiographic, haematological, biochemical, and histopathological findings were evaluated by pairwise comparisons. The findings were consistent and similar. No statistically significant difference was found for a finding disturbing the biocompatibility. Histopathological examinations showed that coating biomaterials did not resorb over the course of 15, 30, and 45 days. It is thus revealed that the content is biocompatible. However, it has been concluded that it is necessary to increase the physical strength of the coating surface against sterilization and surgical procedures. As a result, based on the interpretations of the clinical, radiographic, haematological, biochemical, and histopathological findings, the biocompatibility of HA/h-BN/Cs/Ct1 biocomposite materials has been revealed.
Keywords : Biomaterial, biocomposite, implant coating, boron nitride, electrophoretic deposition, experimental