In vivo Effects of Malathion on Glutathione-S-Transferase and Acetylcholinesterase Activities in Various Tissues of Neonatal Rats

Authors : Suna TİMUR, Seçil ÖNAL

Pages : 247-252

View : 15 | Download : 6

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Glutathione-S-transferase insert ignore into journalissuearticles values(GST); has been reported to play an important role in the detoxification of several chemical compounds, including pesticides. Organophosphate pesticides are potent inhibitors of acetylcholinesterase insert ignore into journalissuearticles values(AChE);. The present study was conducted to assess the in vivo effects of the organophosphate pesticide malathion on the activity of GST and AChE and the protein levels of different organs in neonatal rats. GST activity increased approximately two-fold in adult female rats fed malathion, whereas AChE activity decreased less than 20% of the control in the liver. Similarly, liver and heart GST activities insert ignore into journalissuearticles values(0.14 and 0.035 U/mg protein, respectively); were also increased approximately two-fold in neonatal rats, but in the brain a decrease in GST activity insert ignore into journalissuearticles values(0.074 U/mg protein); was observed. The acetylcholinesterase activity in the liver, brain, kidney and lung insert ignore into journalissuearticles values(0.002, 0.035, 0.046, and 0.018 U/mg protein, respectively); seemed to be significantly decreased compared with the control. There was no significant change in protein contents. In conclusion, it is suggested that malathion has some biochemical effects on rats.
Keywords : Glutathione S transferase GST, Acetylcholinesterase AChE, Glutathione GSH, Enzyme induction, Organophosphate