Cardiotoxic effects of enrofloxacin on electrophysiological activity, cardiac markers, oxidative stress, and haematological findings in rabbits

Authors : RAMAZAN DURGUT, OKTAY HASAN ÖZTÜRK, AHMET NACAR, ALİYE SAĞKAN ÖZTÜRK

Pages : 513-521

View : 20 | Download : 3

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The aim of this research was to investigate the effect of normal and high doses of enrofloxacin on basal electrocardiographic insert ignore into journalissuearticles values(ECG); parameters including corrected QT insert ignore into journalissuearticles values(QTc); values along with biochemical and haematological findings in healthy rabbits. In total 21 New Zealand rabbits were used. The animals were randomly divided into three groups including 7 rabbits in each. The normal dose insert ignore into journalissuearticles values(5 mg/kg); of enrofloxacin and a toxic dose insert ignore into journalissuearticles values(50 mg/kg); were given intravenously in group 1, and the normal dose was given for 6 weeks in group 2. The last group was designated as a negative control insert ignore into journalissuearticles values(group 3);. ECG, serum biochemistry parameters, and total antioxidant capacity insert ignore into journalissuearticles values(TAC); and total oxidant status insert ignore into journalissuearticles values(TOS); were determined every week. At the end of the experiment, necropsy was performed and histology was evaluated. Some oxidative parameters were measured in the heart tissue. No cardiotoxic effect was observed on ECG, in biochemical or haematological findings, or macroscopic or histological findings in groups 2 and 3. The results indicated that enrofloxacin is not harmful for the heart in clinically healthy rabbits at normal and toxic doses compared with the negative control group in terms of ECG, biochemical or haematological findings, or macroscopic or histological findings.
Keywords : Rabbit, enrofloxacin, ECG and QT prolongation, haematology, biochemistry