Effects of aluminum, copper, and titanium nanoparticles on some blood parameters in Wistar rats

Authors : ESİN GÜLNAZ CANLI, MUSTAFA CANLI

Pages : 259-266

View : 12 | Download : 6

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :In this study, Al2O3, CuO, and TiO2 nanoparticles insert ignore into journalissuearticles values(NPs); were individually administered to 60 mature female rats via oral gavage insert ignore into journalissuearticles values(0, 0.5, 5, and 50 mg/kg b.w. per day); for 14 days and then responses of ATPases in the erythrocytes, total oxidant status insert ignore into journalissuearticles values(TOS);, total antioxidant status insert ignore into journalissuearticles values(TAS);, and liver enzyme insert ignore into journalissuearticles values(alkaline phosphatase, ALP; alanine transaminase, ALT; aspartate transaminase, AST); levels in the serum were determined. There were sharp decreases in Na,K-ATPase activity in the erythrocytes following NP exposures. All doses of CuO caused significant insert ignore into journalissuearticles values(P < 0.05); inhibitions in Na,K-ATPase activity insert ignore into journalissuearticles values(up to 94%);, while only higher doses of Al2O3 and TiO2 inhibited insert ignore into journalissuearticles values(76%-80%); the activity of Na,K-ATPase. Oppositely, the activities of Ca-ATPase insert ignore into journalissuearticles values(up to 274%); and Mg-ATPase insert ignore into journalissuearticles values(up to 290%); increased significantly following TiO2 exposures. TOS levels significantly increased following Al2O3 insert ignore into journalissuearticles values(167%); and CuO insert ignore into journalissuearticles values(240%); exposures, though TAS levels did not change significantly in any of the exposure groups. The levels of ALP, AST, and ALT increased following NP administrations. Ti-NP increased the levels of all liver enzymes in the serum insert ignore into journalissuearticles values(up to 84%);, while Al-NP insert ignore into journalissuearticles values(58%); and Cu- NP insert ignore into journalissuearticles values(43%); increased only ALP levels. The present study demonstrated evidence of the toxic effects of NPs, as they altered the measured parameters in the blood, and suggests further research to better understand the environmental fate of NPs.
Keywords : Nanoparticles, rat, erythrocyte, serum, toxicity