The Prognostic Role of the D-dimer/Fibrinogen Ratio in Predicting In-hospital Mortality among Sepsis Patients

Authors : Betül Çiğdem Yortanlı, Korhan Kollu

Pages : 630-636

Doi:10.18663/tjcl.1789502

View : 62 | Download : 180

Publication Date : 2026-01-01

Article Type : Research Paper

Abstract :Aims: Dysregulated coagulation and fibrinolysis are central to sepsis pathobiology. This study evaluated the prognostic value of the D-dimer/fibrinogen ratio (DFR) for in-hospital mortality in patients with sepsis. Methods: We analyzed 130 consecutive sepsis patients. The Sepsis-3 criteria were used to establish the diagnosis of sepsis. Demographic and clinical variables, APACHE II, SOFA, D-dimer, fibrinogen, and DFR were recorded at admission. The association between DFR and in-hospital mortality was assessed using multivariable models alongside APACHE II and SOFA. Discrimination was examined with ROC analysis. Results: Non-survivors had higher APACHE II scores, SOFA scores, and DFR than survivors. In multivariable analysis, increasing APACHE II, SOFA, and DFR were each independent predictors of in-hospital mortality. DFR showed high sensitivity and specificity for mortality on ROC analysis. Demographic features did not correlate with survival. Conclusion: DFR is a practical and informative biomarker that independently predicts in-hospital mortality in sepsis, complementing established severity scores. To our knowledge, this is among the first studies to evaluate DFR specifically in septic patients. Our findings suggest that DFR may provide additional value for early risk stratification, but external validation in larger, multicenter cohorts is warranted before its routine implementation.
Keywords : D-dimer/fibrinojen oranı, sepsis, hastane içi mortalite, APACHE II, SOFA, prognostik biyobelirteç

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