Prognostic Value of Serum Uric Acid in Predicting Major Adverse Cardiac Events

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Turkish Journal of Clinics and Laboratory
Cilt: 16 Sayı: 4
Prognostic Value of Serum Uric Acid in Predicting Major Adverse Cardiac Events

Prognostic Value of Serum Uric Acid in Predicting Major Adverse Cardiac Events

Authors : Gamze Yeter Arslan, Serdar Söner

Pages : 591-597

Doi:10.18663/tjcl.1799420

View : 35 | Download : 103

Publication Date : 2026-01-01

Article Type : Research Paper

Abstract :Abstract Aim:Serum uric acid (SUA) has been increasingly recognized as a potential biomarker reflecting inflammation and oxidative stress in cardiovascular diseases. This study aimed to investigate the prognostic value of SUA levels in predicting 30-day major adverse cardiac events (MACE) in patients hospitalized with non–ST-elevation myocardial infarction (NSTEMI). Methods:This retrospective study included 300 consecutive patients diagnosed with NSTEMI who were hospitalized in the Cardiology Department of Gazi Yaşargil Training and Research Hospital between January 2024 and January 2025. Patients with acute or chronic kidney disease, malignancy, or severe systemic inflammatory disorders were excluded. SUA, troponin T, and lipid profile values were obtained on admission. MACE was defined as a composite of cardiovascular death, recurrent myocardial infarction, urgent revascularization, or rehospitalization due to unstable angina within 30 days. Logistic regression analysis was used to determine independent predictors of MACE. Results:MACE occurred in 28.7% of patients (n=86). The median SUA level was significantly higher in patients who developed MACE compared with those who did not (7.5 vs. 6.5 mg/dL, p=0.001). ROC curve analysis demonstrated that SUA predicted 30- day MACE with an AUC of 0.72. In multivariate logistic regression, elevated SUA (OR=1.45, p=0.03), troponin T (OR=1.62, p=0.01), and diabetes mellitus (OR=1.39, p=0.04) were identified as independent predictors. Conclusion:Serum uric acid is an independent and readily available biomarker associated with early adverse cardiac outcomes in NSTEMI. Routine SUA measurement upon admission may enhance short-term risk stratification and guide clinical decision- making in patients with NSTE-ACS.
Keywords : Ürik asit, NSTEMI, MACE, prognostik belirteç, oksidatif stres, inflamasyon

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