Association of Tp-e Interval, Tp-e/QT and Tp-e/QTc Ratios With the Triglyceride–Glucose Index: A Retrospective Cross-Sectional Study

Authors : Ahmet Yılmaz, Enes Çon
Pages : 582-590
Doi:10.18663/tjcl.1820757
View : 82 | Download : 130
Publication Date : 2026-01-01
Article Type : Research Paper
Abstract :Objective: The aim of this study was to evaluate the relationship between the triglyceride glucose (TyG) index, a practical biomarker of insulin resistance, and the electrocardiographic indicators of ventricular repolarisation, namely the Tp–e interval, Tp–e/QT, and Tp–e/QTc ratios. Materials and Methods: This retrospective cross-sectional study was conducted at the Department of Cardiology, Faculty of Medicine, Karamanoğlu Mehmetbey University, between 1 January 2024 and 31 September 2025. The demographic, laboratory, and electrocardiographic data of 200 adult individuals who met the inclusion criteria were retrieved from the electronic record system. The TyG index was calculated from fasting glucose and triglyceride levels, and patients were divided into four quartiles (Q1–Q4) according to their TyG values. Tp–e, Tp–e/QT, and Tp–e/QTc measurements were performed by two independent observers from digital ECG recordings. Intergroup differences were evaluated using the ANOVA test, and relationships were assessed using correlation and multivariate regression analyses. Results: The mean age of participants was 51.5 ± 18.8 years, and 51% were male. With an increase in the TyG index, the Tp–e duration (r = 0.558, p 8.70 predicted the presence of prolonged Tp–e with 77% sensitivity and 72% specificity (AUC = 0.78, p < 0.001). Conclusion: This study is the first to demonstrate an independent association between the TyG index and the Tp–e interval, Tp–e/QT, and Tp–e/QTc ratios. These findings suggest that metabolic stress may contribute to cardiac electrical instability by increasing the heterogeneity of ventricular repolarisation. The TyG index, as an easily calculable parameter, may be a potential biomarker for early detection of subclinical arrhythmic risk.
Keywords : Trigliserd-glukoz indeksi, Tp–e aralığı, Tp–e/QT oranı, Tp–e/QTc oranı, ventriküler repolarizasyon, aritmojenik risk

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