The Prognostic Values of Graded Prognostic Assessment (GPA) Index In Advanced Stage NSCLC Patients With Brain Metastasis

Authors : Ayse KOTEK SEDEF, Emre UYSAL, Tanju BERBER, Necla GÜRDAL, Berna YILDIRIM

Pages : 137-141

Doi:10.18663/tjcl.1240361

View : 17 | Download : 15

Publication Date : 2023-03-23

Article Type : Research Paper

Abstract :Purpose: Graded Prognostic Assessment insert ignore into journalissuearticles values(GPA); is a new prognostic index for patients with brain metastases. Brain metastasis is a common site of metastasis in lung cancers. Lung cancer-specific GPA scoring system is used. We aimed to assess the prognostic and predictive significance of Graded Prognostic Assessment insert ignore into journalissuearticles values(GPA); score in non small-cell lung cancer patients with brain metastasis. Materials and Methods: This study was designed as a hospital-based retrospective observational case-series study. A total of 95 patients with brain metastatic NSCLC patients who were followed in two different oncology centers in Turkey between 2015 and 2021 have been included into this study. They were divided into 3 groups according to their GPA scores. Results: The median age of the patients was 62 insert ignore into journalissuearticles values(range 44-89); years The patients were divided into 3 groups according to their GPA scores. 24 insert ignore into journalissuearticles values(25.2 %); patients had ‘’0-1’’ GPA score, 54 insert ignore into journalissuearticles values(56,8 %); patients had ‘’1,5-2’’ GPA score and 17 insert ignore into journalissuearticles values(18 %); patients had ‘’2,5-3’’ GPA score. The median follow-up time was 11 months and 89 insert ignore into journalissuearticles values(93.7%); patients died during follow-up. Overall survival insert ignore into journalissuearticles values(OS); was 8 months. Patients in the low insert ignore into journalissuearticles values(0-1); GPA scores had worst overall survival than those with higher GPA scores insert ignore into journalissuearticles values(4.7, 12.6 and 18.5 months respectively and p=0,001);. Conclusion: In this study, we have shown that GPA score is useful in evaluating the prognosis of NSCLC patients with brain metastasis
Keywords : GPA, Lung Cancer, Brain Metastasis