Assessment Of Serum Cyanocobalamin Level And Importance In Patients With Hematological Malignancies

Authors : Esra ZEYNELGİL, Özlem DOĞAN, Buğra SAĞLAM, Mehmet ASIL

Pages : 270-273

Doi:10.18663/tjcl.1225685

View : 26 | Download : 21

Publication Date : 2023-06-30

Article Type : Research Paper

Abstract :ABSTRACT Aim: In our study, we planned to investigate the effect of serum cyanocobalamin insert ignore into journalissuearticles values(Vitamin B12); levels at the time of diagnosis in patients with various hematological malignancies. Patients and Methods: Two hundred and one patients between 18-75 years old diagnosed with various hematological malignancies and 30 healthy controls applying to outpatient and inpatient clinics of Hematology Department in Necmettin Erbakan University Meram Faculty of Medicine between 2010-2014 years were included in the study. Demographic and clinical data and laboratory findings of the patients included in the study were recorded retrospectively. Results: A total of 231 patients, 132 men insert ignore into journalissuearticles values(57.1%); and 99 women insert ignore into journalissuearticles values(42.9%);, were included in our study, of which 201 were patients and 30 were healthy controls. The mean serum vitamin B12 concentration of all patients was found as 344.9 ± 279.0 pg/mL. When vitamin B12 levels were analyzed according to diagnostic groups, it was found to be highest in CML insert ignore into journalissuearticles values(596.0 ± 428.3 pg / mL); and ALL insert ignore into journalissuearticles values(524.5 ± 442.6 pg / mL); patients and lowest in AML patients insert ignore into journalissuearticles values(240.9 ± 178, 0 pg / mL);; the difference was statistically significant insert ignore into journalissuearticles values(p <0.001);. Vitamin B12 levels of diagnostic groups were found to have no significant effect on survival. Conclusion: Cyanocobalamin levels were found to be high in patients with hematological malignancies, especially in CML patients. A high level of cyanocobalamin may be helpful in prediction of CML, however prospective studies are required to support this finding.
Keywords : cyanocobalamin, CML, ALL, AML, Vitamin B12