Effect of probiotic supplementation on hospital admission frequency and inflammatory markers in allergic rhinitis and irritable bowel syndrome patients

Authors : Berzan Haznedar, Günay Kozan, Berat Ebik

Pages : 442-448

Doi:10.18663/tjcl.1550711

View : 68 | Download : 107

Publication Date : 2024-09-30

Article Type : Research Paper

Abstract :Aim: This study aimed to investigate the effect of short-term (3-6 months) probiotic use on patients with recurrent allergic rhinitis (AR) and irritable bowel syndrome (IBS), focusing on changes in inflammation indices and hospital admission frequency. Material and Methods: This retrospective study included patients diagnosed with IBS and AR between 2020 and 2021, who used probiotic supplements for 3 to 6 months. Clinical data, including demographic characteristics, systemic inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), hemograms before and after probiotic use, and AR-related admission numbers, were collected. The probiotic intervention was compared to a control group receiving standard IBS treatment without probiotics. Results: Of the 135 patients evaluated, a significant reduction in AR-related hospital admission frequency was observed in the probiotic-treated group compared to the control group (p 0.05). Conclusion: Probiotic use for at least 3 months in patients with IBS and AR demonstrated improvements in inflammation indices and a reduction in disease-related hospital admission frequency. This suggests a potential role for probiotics in modulating allergic responses and inflammation, providing a promising adjunctive therapy for managing AR, particularly in individuals with co-existing gastrointestinal conditions.
Keywords : probiyotikler, alerjik rinit, İrritabl barsak sendromu, inflamasyon indeksleri, hastalığa bağlı hastaneye yatış