Inflammatory markers as predictors of late-onset fetal growth restriction: a focus on neutrophil-to-lymphocyte and platelet-to- lymphocyte ratios

Authors : Özge Kahramanoğlu, Koray Gök

Pages : 587-592

Doi:10.18663/tjcl.1577124

View : 37 | Download : 62

Publication Date : 2024-12-31

Article Type : Research Paper

Abstract :Aim: This study evaluates the role of hematologic inflammatory markers, specifically neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), in predicting late-onset fetal growth restriction (FGR). Material and Methods: A retrospective comparative analysis was conducted on 76 pregnancies complicated by late- onset FGR and 100 healthy pregnancies as controls. Maternal blood samples were collected, and hematologic parameters, including NLR and PLR, were recorded. Data analysis compared inflammatory markers between the FGR and control groups to assess the relationship between maternal inflammatory profiles and FGR. Results: NLR was significantly higher in the FGR group compared to the control group (p<0.001), suggesting increased systemic inflammation in pregnancies complicated by FGR. PLR, although elevated in the FGR group, did not show significant differences between groups. Additionally, white blood cell and neutrophil counts were significantly elevated in the FGR group (p<0.001), while Apgar scores at 1 and 5 minutes were notably lower in FGR cases (p<0.01), indicating compromised neonatal outcomes. Conclusion: Our findings suggest that elevated NLR may serve as a valuable inflammatory marker for identifying pregnancies at risk for late-onset FGR. Although PLR showed no significant association, the overall inflammatory profile indicates systemic maternal inflammation’s role in FGR pathogenesis. The use of NLR as a cost-effective and accessible predictive tool could enhance early identification and monitoring of at-risk pregnancies, supporting timely intervention strategies. Further studies are needed to validate these findings and explore the integration of inflammatory markers into routine prenatal care.
Keywords : Fetal Gelişim Geriliği, İnflamasyon, Nötrofil-Lenfosit Oranı, Trombosit-Lenfosit Oranı