EVALUATION OF INFLAMMATORY MARKERS IN CRITICALLY ILL ICU PATIENTS WITH AND WITHOUT ACUTE KIDNEY INJURY

Authors : Kemal Yetiş GÜLSOY, Semiha ORHAN

Pages : 92-96

Doi:10.56150/tjhsl.1284204

View : 49 | Download : 35

Publication Date : 2023-08-31

Article Type : Research Paper

Abstract :Objective: Acute Kidney Injury insert ignore into journalissuearticles values(AKI); is a prevalent condition among patients admitted to the intensive care unit insert ignore into journalissuearticles values(ICU);, with high incidence and increased mortality rates. AKI often induces the elevation of inflammatory biomarkers used for diagnosing infection. This study aimed to investigate changes in inflammatory markers in the setting of AKI. Methods: This retrospective study included patients admitted to the ICUs of Burdur State Hospital between January 2019 and January 2023. Data from 958 patients were analyzed, and AKI was classified by the Acute Kidney Injury Network insert ignore into journalissuearticles values(AKIN); criteria. Only creatinine data were used as information on urine output was not available. The cohort was stratified into following groups: no AKI insert ignore into journalissuearticles values(AKI 0);, b); creatine levels between 1.60 and 2.50 mg/dL insert ignore into journalissuearticles values(AKI I);, creatine levels between 2.51 and 3.99 mg/dL insert ignore into journalissuearticles values(AKI II);, and creatine levels above 4 and receiving renal replacement therapy insert ignore into journalissuearticles values(AKI III);. Results: Of the 958 patients, male and female distribution was 55.1% insert ignore into journalissuearticles values(n= 528); and 44.9% insert ignore into journalissuearticles values(n= 430); respectively. The median age of the study cohort was 79 years insert ignore into journalissuearticles values(IQR=18.3 years);. Neutrophil-to-lymphocyte ratio, procalcitonin, and C-reactive protein levels were found to increase significantly in direct relation to the severity of AKI insert ignore into journalissuearticles values(p<0.001);. Furthermore, in infected patients, these inflammatory biomarkers were found to increase in parallel with the severity of AKI compared to non-infected patients insert ignore into journalissuearticles values(p<0.001);. Conclusion: Inflammatory biomarkers rise as the severity of renal failure increases. The combined use of neutrophil-to-lymphocyte ratio, procalcitonin, and C-reactive protein levels in patients with renal failure would be more effective for diagnosing infection.
Keywords : Infection, Inflammatory Biomarker, Renal Failure, Intensive Care

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