Effects of Cigarette Smoking on Total and Salivary Cortisol Levels

Authors : Gülşah ELBÜKEN

Pages : 78-82

Doi:10.46310/tjim.765580

View : 21 | Download : 9

Publication Date : 2020-07-29

Article Type : Research Paper

Abstract :Aim: Although there are some studies regarding the effects of cigarette smoking on serum total cortisol insert ignore into journalissuearticles values(TC); and salivary cortisol insert ignore into journalissuearticles values(SaC); levels, the results are still not conclusive. For this purpose, we aimed to determine the effects of cigarette smoking on TC and SaC levels in a small sample of healthy volunteers. Study design: Twenty-five insert ignore into journalissuearticles values(12 females and 13 males); smokers with a mean age of 42.6± 15 years and 25 insert ignore into journalissuearticles values(12 females and 13 males); age- and gender-matched healthy non-smokers insert ignore into journalissuearticles values(mean age:40.8± 14.5 years); were enrolled in the study. Hypothalamic-pituitary-adrenal insert ignore into journalissuearticles values(HPA); axis was evaluated by baseline TC and SaC levels, and TC and SaC responses to standard dose insert ignore into journalissuearticles values(250 µg); ACTH stimulation test. TC and SaC levels were obtained under baseline and stimulated conditions. Results: Although mean TC and SaC levels were higher in smokers versus non-smokers, a statistically significant difference was not found between the two groups. Conclusion: TC and SaC levels were not statistically different between smokers and non-smokers. Further studies with a larger sample size are needed to draw definitive conclusions.
Keywords : smoking, serum total cortisol, salivary cortisol, ACTH stimulation test