Clinical Aspects of Vitamin D Deficiency in Multiple Sclerosis

Authors : Elif Nalan TOLGAY, Meral SEFEROGLU, Özlem TAŞKAPILIOĞLU, Ömer Faruk TURAN

Pages : 105-112

Doi:10.46310/tjim.771364

View : 20 | Download : 9

Publication Date : 2020-10-29

Article Type : Research Paper

Abstract :Introduction: Multiple Sclerosis insert ignore into journalissuearticles values(MS); is a multifactorial, immune-mediated disorder that occurs in genetically predisposed people. Vitamin D might be an important environmental factor in the development and prevention of MS disease. We aimed to investigate the role of vitamin D in MS disease activity. Material and Methods: The study was designed as a prospective study. Thirty-two patients and 15 healthy subjects were included. Variables were MS disease duration, number of relapses, Expanded Disability Status Scale insert ignore into journalissuearticles values(EDSS); scores, serum vitamin D levels, assessments through neuropsychological tests relevant to depression, cognition, anxiety and fatigue. Results: The mean age of the subjects was 32.6±6.9 years. A significant positive correlation was found between the vitamin D level during relapse and remission. A statistically significant difference was found between the patients in relapse and controls in serum vitamin D levels insert ignore into journalissuearticles values(p=0.002);. A statistically significant difference was found between the patients in relapse and patients in remission, in serum vitamin D concentrations insert ignore into journalissuearticles values(p<0.001);. Statistically significant differences were found between the patients in relapse and controls in MMSE, Beck Depression Inventory, Benedict`s Cognition Test, Fatigue Severity Scale, PASAT, State-Trait Anxiety Inventory scores insert ignore into journalissuearticles values(p=0.01, p<0.001, p=0.01, p<0.001, p=0.007, p<0.001 and p<0.001, respectively);. Conclusion: Vitamin D in association with other therapies may prevent the progression of MS-related disabilities and the relapses in RRMS. Vitamin D levels may have effects on the symptoms insert ignore into journalissuearticles values(depression, anxiety, cognitive deterioration, and fatigue); which are frequently seen in the course of MS.
Keywords : Multiple Sclerosis, Vitamin D, Cognition, Disability, Psychiatric comorbidity