Assessment of The Performances of Hepatitis C Virus Viral Markers, Age-Platelet Index and Aspartate aminotransferase to Alanine Aminotransferase Ratio Scores, in Predicting Liver Histopathology

Authors : Ayfer BAKIR, Mustafa GÜNEY, Harun ERDAL, Özlem YAVUZ, Armağan GÜNAL, Mustafa GÜLŞEN, Mehmet Tevfik YAVUZ

Pages : 6-12

Doi:10.46310/tjim.825814

View : 17 | Download : 13

Publication Date : 2021-01-29

Article Type : Research Paper

Abstract :Introduction This study aimed to reveal the utility of age-platelet insert ignore into journalissuearticles values(AP); index and aspartate aminotransferase insert ignore into journalissuearticles values(AST); to alanine aminotransferase insert ignore into journalissuearticles values(ALT); ratio insert ignore into journalissuearticles values(AAR);, which are non-invasive markers, in patients with chronic Hepatitis C virus insert ignore into journalissuearticles values(HCV); infection in prediction of fibrosis and evaluate whether viral markers could be used for that purpose or not. Methods A total of treatment-naïve 49 patients with chronic HCV who underwent liver biopsy were included in this retrospective study. Anti-HCV S/CO and HCV-RNA viral load insert ignore into journalissuearticles values(copy/ml); values measured simultaneously with biopsy were determined. AP index and AAR score were calculated and compared. Results Staging of liver biopsy samples of 49 HCV patients was assessed. Comparable diagnostic accuracies of AP index and AAR in prediction of significant fibrosis insert ignore into journalissuearticles values(F≥2); were showed with ROC curve analysis. The areas under the ROC insert ignore into journalissuearticles values(AUROCs); were 0.713 and 0.506 respectively. Diagnostic accuracy of API in prediction of significant fibrosis was superior to that of AAR insert ignore into journalissuearticles values(p=0.03);. AUROC of HCV-RNA viral load in prediction of F≥2 was 0.531. Anti-HCV S/CO value insert ignore into journalissuearticles values(AUROC=0.464); was not found as a suitable marker in prediction of fibrosis. Conclusions AP index, AAR score and HCV viral load among non-invasive markers assessed in this study were useful in predicting significant fibrosis. Especially API was the most useful test in predicting significant fibrosis. AP index can be preferred in patients with near normal ALT values.
Keywords : liver fibrosis, non invasive test, AST to ALT ratio AAR, age platelet AP, index, HCV viral load, anti HCV