Do Hormonal Disorders Contribute to the Pathology of Hereditary Angioedema?

Authors : Gökhan AYTEKİN, Hakan OZER, İsmail BALOĞLU, Fatih ÇÖLKESEN, Eray YILDIZ, Şevket ARSLAN, Ahmet ÇALIŞKANER

Pages : 155-162

Doi:10.46310/tjim.1066357

View : 53 | Download : 11

Publication Date : 2022-10-29

Article Type : Research Paper

Abstract :Objective: Hereditary angioedema insert ignore into journalissuearticles values(HAE); is an autosomal dominant disorder characterized by recurrent episodes of angioedema without urticaria or pruritus. In this study, we compared the levels of anabolic hormones, such as insulin, insulin-like growth factor, growth hormone, and thyroid hormones insert ignore into journalissuearticles values(thyroid-stimulating hormone [TSH], triiodothyronine [T3], and thyroxine [T4]);, and the levels of hormones that are considered catabolic, such as adrenocorticotrophic hormone insert ignore into journalissuearticles values(ACTH); and cortisol, between HAE patients and controls. We also discuss the contribution of these hormones to the pathophysiology of HAE. Methods: The study included 18 patients insert ignore into journalissuearticles values(9 diagnosed with HAE type 1 and 9 with HAE type 2); who were followed in the immunology and allergy clinic between January 2013 and January 2020. The control group comprised 28 age- and gender-matched subjects. Results: The HAE type 1, HAE type 2, and control groups showed no significant differences in insulin, insulin-like growth factor, ACTH, cortisol, TSH, or T4 levels. The C-peptide and T3 levels were significantly different between the groups insert ignore into journalissuearticles values(p = 0.011 and p = 0.027, respectively); insert ignore into journalissuearticles values(Table 3);. Post-hoc pairwise comparison revealed no significant difference in C-peptide level among the groups, but a significant difference in the T3 level was detected between HAE type 1 patients and controls insert ignore into journalissuearticles values(p = 0.029); Conclusions: Although no significant differences were observed in other anabolic hormone levels between the controls and HAE patients, T3 levels were significantly lower in type 1 HAE patients. Close monitoring of low T3 levels is required, particularly in patients with type 1 HAE.
Keywords : Hereditary angioedema, anabolic hormones, T3

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