Comparison of the expression of GATA-3 protein from the transcription factor family and pathological prognostic parameters in invasive ductal carcinomas of the breast

Authors : Leymune PARLAK, Olcay KANDEMİR

Pages : 163-173

Doi:10.46310/tjim.1090713

View : 22 | Download : 20

Publication Date : 2022-10-29

Article Type : Research Paper

Abstract :Background GATA binding protein 3 insert ignore into journalissuearticles values(GATA-3); is one of the six transcription factor family members and is important for glandular development in the breast. Its expression becomes important in breast cancer. We aimed to compare GATA-3 immunoreactivity and pathological prognostic factors in patients with invasive ductal carcinoma. Material and Methods Our study was conducted retrospectively with 300 breast invasive ductal carcinoma patients who were operated on in our hospital between May 2013 and June 2014. Patient reports, slides and blocks in the pathology archive were scanned. GATA-3 immunohistochemical insert ignore into journalissuearticles values(IHC); staining was evaluated according to the nuclear staining, intensity and percentage. The relationship between clinicopathological prognostic parameters and GATA-3 IHC staining results was investigated. Results A positive staining was observed in 286 insert ignore into journalissuearticles values(95.3%); cases. According to the GATA-3 staining intensity and percentage, 210 insert ignore into journalissuearticles values(70%); cases stained strongly and 246 insert ignore into journalissuearticles values(82%); stained +4, respectively. There was a significant relationship between GATA-3 immunoreactivity with ER, PR, Cerb-B2, Ki-67, mitotic degree, mitotic count and histological grade. Conclusions There was a correlation between the high expression of GATA-3 and good prognostic markers. Hormone receptors can be evaluated with Cerb-B2 and Ki-67 and used as prognosis determinants in breast cancers. They can be used to identify both primary and secondary breast tumors.
Keywords : GATA 3, Breast cancer, Prognostic markers, Hormone receptor