Biological Agent Use in Behçet`s Patients Who Are Resistant to Conventional Treatments: A Multidisciplinary Retrospective Study

Authors : Burcu YAĞIZ, Belkıs Nihan COŞKUN, Zeliha Kübra ÇAKAN, Gamze UÇAN GÜNDÜZ, Özgür YALÇINBAYIR, Serkan YAZİCİ, Hayriye SARICAOĞLU, Hüseyin Ediz DALKILIÇ, Yavuz PEHLİVAN

Pages : 33-40

Doi:10.46310/tjim.1144532

View : 16 | Download : 15

Publication Date : 2023-01-29

Article Type : Research Paper

Abstract :Background Comparing treatment modalities is difficult in Behcet\`s syndrome, even if tumour necrosis factor-alpha insert ignore into journalissuearticles values(TNF-α); inhibitors are a treatment option for all involvements resistant to conventional therapy. This study evaluated how different departments dealt with treatment, particularly with TNF-α inhibitors. Material and Methods The study comprised 111 patients from our Behcet\`s syndrome cohort who were treated with TNF-α inhibitors between 2010 and 2019. Data on patients were retrieved retrospectively from the rheumatology, ophthalmology, and dermatology clinics\` patient records. Results Patients followed up in rheumatology insert ignore into journalissuearticles values(n: 40); were classified as Group 1, and patients followed up in ophthalmology insert ignore into journalissuearticles values(n: 49); and dermatology insert ignore into journalissuearticles values(n: 5); as Group 2. In Group 1, genital ulcers, erythema nodosum insert ignore into journalissuearticles values(p=0.009, p=0.003, respectively);, lower extremity deep vein thrombosis, arterial aneurysm and neurological involvement were more common insert ignore into journalissuearticles values(p=0.005, p=0.008, p=0.001, respectively);. In Group 2, the use of cyclosporine and interferon-α before the anti-TNF agent was higher insert ignore into journalissuearticles values(p<0.001, p<0.001, respectively);, and the use of cyclophosphamide were higher in Group 1 insert ignore into journalissuearticles values(p<0.001);. Both groups preferred infliximab, and ocular involvement was the most common reason for starting. Conclusions While TNF-α inhibitors were chosen equally across departments, conventional medicines, including cyclosporine, cyclophosphamide, and interferon-α, were not. This choice was determined by the departments\` experience and the clinical traits that predominated.
Keywords : Behcet, dermatology, ophthalmology, rheumatology, TNF α inhibitor