Bone Mineral Density in Lung Transplant Recipients: Experience of A Referral Lung Transplantation Center

Authors : Pınar ATAGÜN GÜNEY, İlim IRMAK, Ayse Nigar HALİS, Ertan SARIBAŞ

Pages : 156-162

Doi:10.46310/tjim.1206443

View : 57 | Download : 87

Publication Date : 2023-07-29

Article Type : Research Paper

Abstract :Background Osteoporosis is a well-recognized and curable complication of lung transplantation. This study aimed to determine the degree of bone mineral density before transplantation and to evaluate the risk factors associated with osteoporosis in lung transplant patients. Material and Methods The bone mineral density of 72 patients who underwent lung transplantation with the diagnosis of end-stage lung diseases between December 2016 and April 2021 was evaluated in the pre-transplant period. Results 58 of 72 patients who underwent lung transplantation were included in the study. The age range of the cases was 14-64 insert ignore into journalissuearticles values(mean 48); years, and 14 insert ignore into journalissuearticles values(23.7%); were female. The presence of osteoporosis in the study population was 49.2% insert ignore into journalissuearticles values(n: 29);, and osteopenia was 40.7% insert ignore into journalissuearticles values(n: 24);. Osteoporosis was significantly more common in patients with younger age and lower body mass index insert ignore into journalissuearticles values(p = 0.024 and p = 0.009, respectively);. And most down forced expiratory volüme 1 values were in patients with osteoporosis insert ignore into journalissuearticles values(p < 0.001 and p = 0.008, respectively);. Steroid usage insert ignore into journalissuearticles values(OR: 0.06, 95% CI: 0.01-0.36, p = 0.002); in T score insert ignore into journalissuearticles values(femur neck); and 1.25 dihydroxy vitamin D insert ignore into journalissuearticles values(OR: 1.15, 95% CI: 1.03-1.28, p = 0.012); in T score insert ignore into journalissuearticles values(lumbal spine); were found to be independent predictors of osteoporosis according to multivariate analyzes. Conclusions A significant proportion of patients with end-stage lung disease undergoing lung transplantation have osteoporosis and osteopenia. Interestingly, the candidates were similarly affected despite the variety of underlying conditions. Since osteoporosis is treatable, strict follow-up and treatment management are recommended before referral for transplant candidates.
Keywords : Lung Transplantation, Osteoporosis, End stage lung diseases