Investigation of The Effect of Aminoglycosides on Angiotensin Converting Enzyme (ACE)

Authors : Sevim ÇİFTÇİ YEGİN, Yeter DEĞER, Semiha DEDE, Fatmagül YUR

Pages : 67-71

Doi:10.47748/tjvr.887175

View : 18 | Download : 5

Publication Date : 2021-11-15

Article Type : Research Paper

Abstract :Objective: The research attention to nephrotoxicity from antibiotics insert ignore into journalissuearticles values(as aminoglycosides);, non-steroidal anti-inflammatory drugs, and antifungals, angiotensin-converting enzyme insert ignore into journalissuearticles values(ACE); inhibitors. Several drugs have resulted in produce an adverse effect on kidneys. Angiotensin-converting enzyme insert ignore into journalissuearticles values(ACE); is a component of the renin-angiotensin system insert ignore into journalissuearticles values(RAS);, which leads to the conversion of angiotensin-I to angiotensin-II in vascular tissues. The present study aimed to determine serum ACE activity in rats with an aminoglycosine. Material-Method: In this study, two different groups formed, the control group insert ignore into journalissuearticles values(10 rats/Wistar-albino female); and the experimental group insert ignore into journalissuearticles values(30 rats/Wistar-albino female); administered aminoglycosine insert ignore into journalissuearticles values(Amikacin);. Aminoglycosine was administered intraperitoneally to the experimental group at a single dose of 15 mg/kg body weight at the same time each day for 14 days. The control group implemented physiological water instead of aminoglycosine at the same rate. Result: When the groups compared according to the statistic results, it is observed that there was a significant increase in the experimental group according to the control group insert ignore into journalissuearticles values(p˂0.001);. Conclusion: As a result, it was determined that aminoglycosin administered increased serum ACE activity and it was concluded that it may be useful to investigate the possibilities to evaluate it as a risk factor and indicator in the development of hypertension
Keywords : Aminoglycosides, Angiotensin Converting Enzyme, Antibiotics