A review on recent electroanalytical methods for the analysis of antiviral COVID-19 drugs

Authors : Deniz EMRE, Nuran ÖZALTIN, Selehattin YILMAZ

Pages : 1-8

Doi:10.51435/turkjac.935765

View : 47 | Download : 5

Publication Date : 2021-06-29

Article Type : Review Paper

Abstract :Currently, there are no specific drugs for the severe acute respiratory syndrome coronavirus 2 insert ignore into journalissuearticles values(SARS-CoV-2); infection, designated as coronavirus disease 2019 insert ignore into journalissuearticles values(COVID-19);. Several therapeutic options including antiviral, antithrombotic, immunosuppressive, and anti-rheumatic drugs are researched all over the world. Analytical methods are needed in every step of innovation, research, development, and manufacturing process of pharmaceuticals, therefore new analytical methods for pharmaceuticals are developed and validated increasingly over time. In this review, recent reports on electroanalytical techniques for the determination of selected COVID-19 drugs, favipiravir insert ignore into journalissuearticles values(FAV);, remdesivir insert ignore into journalissuearticles values(REM);, lopinavir insert ignore into journalissuearticles values(LOP); / ritonavir insert ignore into journalissuearticles values(RIT);, and hydroxychloroquine insert ignore into journalissuearticles values(HCQ); were emphasized. Electroanalysis of antiviral active pharmaceutical ingredients carried out at various modified or non-modified electrodes by cyclic voltammetry insert ignore into journalissuearticles values(CV);, linear sweep voltammetry insert ignore into journalissuearticles values(LSV);, differential pulse voltammetry insert ignore into journalissuearticles values(DPV);, and square wave voltammetry insert ignore into journalissuearticles values(SWV); were compiled from the literature. The effects of supporting electrolyte and pH on the current and potential of the analytical signal were evaluated. Scan rate results obtained by the CV method showed whether the redox process of the drug active ingredient diffusion or adsorption controlled at the electrode used in the selected solvent-supporting electrolyte and pH systems. Linearity range and the limit of detection insert ignore into journalissuearticles values(LOD); of applied electroanalytical methods were compared by combining the results obtained from drug active ingredients given in references.
Keywords : Antiviral drugs, Pandemic, Coronavirus, COVID 19, Analysis, Determination, Electroanalytical methods

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