Genetic factors and anterior cruciate ligament injury risk in professional football players: COL3A1 (rs1800255) and COL5A1 (rs12722) polymorphisms

Authors : Gökhan İPEKOĞLU, Halil İbrahim ÇAKIR, Nihan BOZKURT, Alpay BÜLBÜL, Sadegul Tuncer SAVKİN, Necdet APAYDIN

Pages : 195-203

Doi:10.31459/turkjkin.1329105

View : 55 | Download : 39

Publication Date : 2023-09-30

Article Type : Research Paper

Abstract :This study was conducted to investigate the genotype and allele distributions of COL3A1 insert ignore into journalissuearticles values(rs1800255); and COL5A1 insert ignore into journalissuearticles values(rs12722); polymorphisms of professional footballers who have suffered at least 2 anterior cruciate ligament insert ignore into journalissuearticles values(ACL); injuries non-contact and professional footballers who have never had a ligament injury. The research group consists of 108 professional men\`s football players ACL group insert ignore into journalissuearticles values(n=45);, Control group insert ignore into journalissuearticles values(n=63); with at least 10 years of football background. The results ACL and control groups were compared by Chi-square or Fischer’s exact test. There were no significant differences noted neither in terms of genotype distribution of COL3A1 insert ignore into journalissuearticles values(rs1800255); nor A-allele frequency distribution between control insert ignore into journalissuearticles values(CON); and ACL group. A highly significant difference in the allele distribution was noted for COL5A1 insert ignore into journalissuearticles values(rs12722); with the T-allele significantly less frequent in CON than ACL. The TT genotype compared to the C alleles insert ignore into journalissuearticles values(TC + CC); showed significant relationship between the TT genotype and ACL injury potential in the dominant model. However, it was not showing significance in the recessive insert ignore into journalissuearticles values(TT + TC vs. CC);. In conclusion, it can be said that professional football players who have the COL5A1 rs12722 C allele have about 2 times lower risk of anterior cruciate ligament injury. In the COL3A1 rs1800255 polymorphism, there is no relationship between the groups in terms of genotypes and allele distribution.
Keywords : ACL, COL3A1, COL5A1, gene, football, polymorphism