Effects of Repeated Low-Dose N-Acetylcysteine Administration on Oxidative Stress and Growth Performance in Saanen Goat Kids During Weaning

Authors : Feyyaz Kaya, Gökhan Bozkurt

Pages : 176-180

Doi:10.36483/vanvetj.1702939

View : 103 | Download : 199

Publication Date : 2025-11-30

Article Type : Research Paper

Abstract :Oxidative stress related to the weaning period in ruminants may increase susceptibility to diseases. However, information regarding the physiological changes associated with oxidative stress in goats during the weaning period is limited. In this study, twenty healthy male Saanen goat kids were randomly assigned to treatment and control groups, at approximately seventy-five days of age. N-acetylcysteine (NAC) was administered intramuscularly at a dose of 15 mg/kg to the treatment group two days before and for seven days following weaning. Blood samples were collected from both groups two days before, seven days after, and fourteen days after weaning. Total antioxidant capacity (TAC) and total oxidant status (TOS) were measured in the serum samples. Additionally, the body weights of all kids were recorded on the blood sampling days. No significant differences were found between groups in terms of body weight, TAC, TOS, and oxidative stress index (OSI). However, there were significant differences within groups in TOS, OSI, and live weight analysis. In conclusion, although low doses of NAC were not significantly effective in improving growth rates, they did temporarily reduce TOS levels.
Keywords : Büyüme Oranı, Oğlak, N-Asetilsistein, Oksidatif Stres, Sütten Kesme

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