ASSOCIATION OF N-TERMINAL PROHORMONE BRAIN NATRIURETIC PEPTIDE LEVEL AND ECHOCARDIOGRAPHIC LEFT VENTRICULAR SYSTOLIC OR DIASTOLIC DYSFUNCTION IN NON-ACUTE DYSPNEA

Authors : Pelin KARACA ÖZER, Elif AYDUK GOVDELI

Pages : 1-9

View : 19 | Download : 17

Publication Date : 2023-02-28

Article Type : Research Paper

Abstract :Objective: The aim of the study was to evaluate serum N-terminal prohormone brain natriuretic peptide insert ignore into journalissuearticles values(NT-proBNP); level and evidence of left ventricular insert ignore into journalissuearticles values(LV); systolic dysfunction insert ignore into journalissuearticles values(SD); or diastolic dysfunction insert ignore into journalissuearticles values(DD); in non-obese patients with non-acute dyspnea. Methods: This study retrospectively evaluated the serum NT-proBNP level and LV SD or DD from transthoracic echocardiography insert ignore into journalissuearticles values(TTE); in patients with non-acute dyspnea between October 2020 and October 2021. The normal limit for the serum NT-proBNP level insert ignore into journalissuearticles values(125 pg/ml); was used as the cut-off value. Results: Ultimately, 435 patients were included in the study. In 61% of the patients insert ignore into journalissuearticles values(n=264);, the NT-proBNP level was elevated insert ignore into journalissuearticles values(≥ 125 pg/ml);. There was no evidence of SD or DD in 56% of the patients insert ignore into journalissuearticles values(n=147); with ≥ 125 pg/ml. The patients whose NT-proBNP ≥ 125 but who had no SD or DD had a significantly higher H2FPEF score ≥ 6, atrial fibrillation, malignancy, previous COVID-19, and need for hospitalization than the patients whose NT-proBNP < 125 and who had no SD or DD insert ignore into journalissuearticles values(13% vs. 4%; 5% vs. 1%; 16% vs. 9%; 29% vs. 5%; and 25% vs. 11%, respectively);. An NT-proBNP value < 752.1 pg/ml excluded SD with 72.5% sensitivity and 83.1% specificity and < 350.3 pg/ml excluded DD with 71.3% sensitivity and 75.5% specificity. Conclusion: A high NT-proBNP value does not always indicate SD or DD. NT-proBNP measurement may detect not only overt heart failure but also subclinical LV dysfunction in various clinical entities, in addition to adding prognostic significance in non-acute dyspnea.
Keywords : kalp yetmezliği, NT proBNP, dispne