Does aspartate aminotransferase platelet ratio index predict gestational diabetes mellitus? A retrospective cohort study.

Authors : Müjde Can İBANOĞLU, Seval YILMAZ ERGANİ, Büşra ŞAHİN, Hande Nur ONCU, Cantekin İSKENDER, Yaprak USTUN

Pages : 92-97

View : 20 | Download : 15

Publication Date : 2023-02-28

Article Type : Research Paper

Abstract :Objective: Our aim was to determine the significance of aspartate aminotransferase platelet ratio index insert ignore into journalissuearticles values(APRI);, neutrophil to lymphocyte ratio insert ignore into journalissuearticles values(NLR);, and platelet-to-lymphocyte ratio insert ignore into journalissuearticles values(PLR); in predicting gestational diabetes mellitus insert ignore into journalissuearticles values(GDM); at first trimester screening in a retrospective study of pregnant women. Method: In this study, a retrospective analysis of pregnant women insert ignore into journalissuearticles values(n=216); screened at the antenatal clinic and diagnosed with gestational diabetes between 24-28 weeks of gestation was performed. APRI score, NLR and PLR were calculated in the blood of these pregnant women in the first trimester and compared with the results of patients in the control group insert ignore into journalissuearticles values(n=250);. Results: The ROC -analysis for APRI yielded an AUC value of 0.489 insert ignore into journalissuearticles values(p=0.684);. Maternal age was found to be an independent risk factor for GDM. The risk increased 1.162-fold with increasing maternal age insert ignore into journalissuearticles values(p < 0.001);. The optimal cutoff value for NLR was 3.55, sensitivity was 65%, specificity was 49%, and the area under the ROC curve was 0.544. Conclusion: In the results we compared with those of the control group, we found no significant change in APRI value and PLR. However, we found that NLR has a predictive value for GDM.
Keywords : gestational diabetes mellitus, aspartate aminotransferase platelet ratio index, liver fibrosis, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio