The effects of Vitamin D levels on pregnancy outcomes in patients receiving frozen embryo transfer

Authors : Merve ÇAKIR KÖLE, Emre KÖLE, Gökşen GÖRGÜLÜ, Barış CANDAN, Ahmet GÜLLÜOĞLU, Emek DOĞER, Lale AKSOY

Pages : 38-43

View : 20 | Download : 14

Publication Date : 2023-02-28

Article Type : Research Paper

Abstract :Objective: The aim of this study is to evaluate the effects of 25-OH vitamin D on pregnancy outcomes in infertile patients undergoing a frozen embryo transfer. Methods: In this prospective, single-blind study conducted at Kocaeli University Medical Faculty Hospital, Center for Assisted Reproductive Techniques, baseline serum levels of 25-OH vitamin D were measured at the start of treatment in 276 infertile patients who were scheduled to undergo frozen embryo transfer insert ignore into journalissuearticles values(FET);. Cases with 25-OH-D vitamin levels lower than the level of deficiency insert ignore into journalissuearticles values(<20 ng/ml, group A, n=48); and higher than the level of deficiency insert ignore into journalissuearticles values(≥20 ng/ml, group B, n=44); were compared in terms of the rates of pregnancy as an outcome of the FET cycle, clinical pregnancy, ongoing pregnancy, live birth, implantation, pregnancy loss, and multiple pregnancy. Results: Cases in groups 1 and 2 had similar demographic characteristics, and the serum AMH levels, one of the cycle follow-up parameters, were statistically significantly higher in group 1 compared to group 2 insert ignore into journalissuearticles values(p=0.014);. Pregnancy insert ignore into journalissuearticles values(41.6% vs. 31.8%);, clinical pregnancy insert ignore into journalissuearticles values(35.4% vs. 25%);, ongoing pregnancy insert ignore into journalissuearticles values(25% vs. 18.2%);, live birth insert ignore into journalissuearticles values(20.8% vs. 18.2%);, pregnancy loss insert ignore into journalissuearticles values(18.8% vs. 13.6%); and twin pregnancy insert ignore into journalissuearticles values(4.2% vs. 9.1%); were similar between the groups insert ignore into journalissuearticles values(p=0.328, p=0.278, p=0.428, p=0.749, p=0.507, p=0.421, respectively);. Conclusion: There was no correlation between pregnancy outcomes from frozen embryo transfer and baseline serum 25-OH vitamin D levels obtained at the start of treatment. There is no indirect evidence showing that vitamin D level exerts its effects on fertility through endometrial receptivity and the implantation process.
Keywords : Donmuş Embriyo Transferi, Gebelik Sonucu, 25 OH Vitamin D