Assessment of endothelial dysfunction and vascular stiffness after cholecalciferol according to dialysis modality

Authors : Mehmet Baha AYTAC, Merve Aktaş ÖZGÜR, Kenan DOĞAN, Murat DEVECİ, Özlem KAYABEY, Kenan BEK

Pages : 198-205

View : 32 | Download : 32

Publication Date : 2023-06-30

Article Type : Research Paper

Abstract :ABSTRACT Objective: The risk of developing cardiovascular disease insert ignore into journalissuearticles values(CVD); increases significantly in children with chronic kidney disease insert ignore into journalissuearticles values(CKD); especially with low serum 25- hydroxyvitamin D insert ignore into journalissuearticles values(25OHD); levels. Herein; we aimed to compare the effects of vitamin D deficiency and the impact of cholecalciferol treatment on endothelial functions and vascular stiffness in children with CKD receiving hemodialysis insert ignore into journalissuearticles values(HD);, peritoneal dialysis insert ignore into journalissuearticles values(PD); and non- dialysisinsert ignore into journalissuearticles values(ND);. Methods: 7 HD, 7 PD and 27 ND patient groups consisting of 41 children totally with low 25OHD levels were compared among each other in regards of biochemical parameters, flow-mediated dilatationinsert ignore into journalissuearticles values(FMD); and local arterial stiffness before and after a single dose of 300.000 units of cholecalciferol treatment. Results: There was no difference in FMD and local arterial stiffness values between HD, PD and ND patient groups before vitamin D supplementation. Significant increase in endothelium-dependent FMD was observed in all patient groups after intervention with cholecalciferol; however the improvement in endothelium-independent FMD and local arterial stiffness measurements was demonstrated in patients with PD and ND. Baseline parathormon level was higher in patients on dialysis; at the end of the study, significant decrease was detected only in patient group not receiving diaysis. Conclusions: Endothelial dysfunction and impaired vascular stiffness were determined in children with CKD with low 25OHD levels regardless of the disease severity.. Recovery with cholecalciferol therapy revealed that vitamin D deficiency should be corrected even in early stages of CKD to prevent the development of CVD
Keywords : Damar sertliği, endotel disfonksiyonu, kronik böbrek hastalığı, kolekalsiferol