Polycystic ovary syndrome and oxidative stress

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Avrasya Sağlık Bilimleri Dergisi
Volume:8 Issue:1
Polycystic ovary syndrome and oxidative stress

Polycystic ovary syndrome and oxidative stress

Authors : Şerif Hürriyetoğlu, Ahmet Beyazıt, Ali Hakverdi

Pages : 10-15

Doi:10.53493/avrasyasbd.1426544

View : 38 | Download : 13

Publication Date : 2025-01-31

Article Type : Research Paper

Abstract :Objective: In reproductive age, polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women. Although it is a very common, pathogenesis is still unclear. Oxidative stress is one of the proposed mechanisms. In our study, we aimed to evaluate the clinical and laboratory findings and oxidative stress parameters in PCOS. Methods: In our prospective study, we included 75 PCOS patients, diagnosed according to the Rotterdam criteria, and 75 healthy people as the control group. Participants\\\' demographic data and menstrual cycle patterns were questioned. Lipid profile and insulin resistance were examined. Ferriman-Gallwey scoring and androgen levels were studied to evaluate hirsutism. Superoxide dismutase (SOD), catalase and urotensin-2, which are oxidative stress markers, were measured. Results: The average age of the PCOS group was 23.1 and the control group was 27. Menstrual cycle duration was 47.9 versus 27.5 in the PCOS (p 0.05). In our study, SOD, catalase and urotensin-2 levels were measured to evaluate oxidative stress. All three parameters were found to be higher in the PCOS group (for catalase and urotensin 2 p 0.05). Conclusion: PCOS is a group of syndromes whose etiology is still unclear. It has a wide variety of clinical and laboratory findings. Oxidative stress is one of the theories put forward in pathogenesis.
Keywords : Polikistik over sendromu, Oksidatif Stres, İnsulin Direnci

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