EFFECT OF FK506 ADMINISTRATION IN ALPHA MOTOR NEURONS AFTER PRIMARY AND DELAYED REPAIR OF THE SCIATIC NERVE

Authors : Umut Özsoy, Fatoş Belgin Yıldırım, Bahadır Murat Demirel, Arzu Hızay, Levent Sarıkcıoğlu, Necdet Demir, Gamze Tanrıöver, Bikem Süzen, Nurettin Oğuz

Pages : 30-39

View : 22 | Download : 15

Publication Date : 2016-04-30

Article Type : Research Paper

Abstract :Objectives: FK506 is an effective immunosuppressive drug for treating graft rejection in transplants patients. However, the neuroregenerative effect of FK506 has been well described in the literature. The aim of this study was to investigate the effects of FK506 in alpha motor neurons after primary and delayed repair of sciatic nerve. Methods: Rats insert ignore into journalissuearticles values(n=72); were divided into 6 groups. Control, sham-operated, primary repair FK506 insert ignore into journalissuearticles values(-);, primary repair FK506 insert ignore into journalissuearticles values(+);, delayed repair FK506 insert ignore into journalissuearticles values(-);, and delayed repair FK506 insert ignore into journalissuearticles values(+); groups. Results: After injury, the normal structure of the motor neuron perikarya was maintained by primary repair in the FK506 insert ignore into journalissuearticles values(+); group. In the delayed repair group, beneficial effect of FK506 was found to be less effective. The SFI value reached -50 recovery level in the FK506-treated group earlier than those of not FK506-treated groups. Conclusion: Beneficial effect of FK506 has been approved by functional and ultrastructural data in both of primary and delayed repair groups.
Keywords : delayed repair, FK506, primary repair, regeneration, sciatic nerve