AQUEOUS EXTRACT OF GARLIC (ALLIUM SATIVUM) ADMINISTRATION ALLEVIATES HIGH SALT DIET-INDUCED CHANGES IN THE AORTA OF ADULT WISTAR RATS: A MORPHOLOGICAL AND MORPHOMETRIC STUDY

Authors : Olusola S Saka, A Omobola Komolafe, Oludare Ogunlade, Ahmed A Olayode, Alice A Akinjisola

Pages : 8-15

View : 15 | Download : 15

Publication Date : 2016-04-30

Article Type : Research Paper

Abstract :Objectives: This study was designed to determine the morphometric and histological changes of the wall of the thoracic aorta in high salt-fed adult Wistar rats and the possible ameliorative effects of aqueous extract of garlic insert ignore into journalissuearticles values(Allium sativum);. Methods: Twenty-five healthy female Wistar rats weighing 130–180 g were randomly assigned into five groups of five rats each insert ignore into journalissuearticles values(Groups A, B, C, D and E);. Rats in Group A were fed with standard laboratory pellets, while Groups B, C, D and E were fed on the high-salt diet for five weeks. Thereafter, daily administration of 50 mg/kg, 100 mg/kg and 150 mg/kg of the garlic extract were giving orally to Groups C, D and E, respectively for 3 weeks while rats in Groups A and B were administered distilled water. The thoracic part of descending aorta at the level of insert ignore into journalissuearticles values(T6–T7); was excised for histological studies. Paraffin sections were stained with haematoxylin and eosin, Masson’s trichrome and Verhoeff-Van Gieson stains. One-way ANOVA was used to analyze data, followed by Student-Newman-Keuls insert ignore into journalissuearticles values(SNK); test for multiple comparisons. Results: High salt diet causes significant histomorphological changes on aorta of rats as evidenced by increase in tunica intima, media and adventitia of the aortic wall and decrease in luminal diameter; these findings were reversed by aqueous garlic extract administration. Conclusion: High salt diet increased the thickness of aortic wall and decreased luminal diameter which were significantly reversed by oral administration of garlic extract.
Keywords : aorta, garlic, heart, high salt fed