Foetal hepatorenal toxicity and intrauterine growth retardation in pregnant Wistar rats treated with artemether

Authors : İdorenyin UDO UMOH, Etukudoh Okon JİMMY

Pages : 1-6

View : 15 | Download : 11

Publication Date : 2018-06-04

Article Type : Research Paper

Abstract :Objectives: Foetal hepatorenal toxicity and foetal morphology were evaluated following artemether administration to pregnant Wistar albino rats. Methods: Twenty pregnant Wistar rats weighing between 180–200 g were divided into four groups insert ignore into journalissuearticles values(n=5, each); with Group 1 serving as the control. Groups 2, 3 and 4 received 1.1 mg, 2.2 mg and 3.3 mg per kilogram body weight artemether, respectively orally, twice daily for three days on day 7, 8 and 9 of pregnancy. The animals were sacrificed on day 20 of pregnancy and foetuses were harvested and evaluated for morphological changes. Foetal body weight and crown-rump length insert ignore into journalissuearticles values(CRL); were measured; alpha-fetoprotein insert ignore into journalissuearticles values(AFP); was assayed using amniotic fluid, and foetal kidney and liver were evaluated histologically for toxicity. Results: There was a significant decrease in body weight, CRL and AFP of the treated groups compared to the control. The foetal liver of the treated groups revealed distorted cytoarchitecture, marked hepatocyte inflammation and hepatic necrosis. The foetal kidney of artemether-treated groups also showed disorganised renal structure, atrophic and degenerated glomeruli with acute tubular necrosis. Conclusion: Artemether administration to pregnant albino rats causes intrauterine growth retardation or stunted growth, as well as foetal hepatorenal toxicity.
Keywords : alpha fetoprotein, artemether, foetal hepatorenal toxicity, pregnancy