Protective role of sildenafil citrate in isoniazid-rifampicin induced histomorphological changes in liver of albino mice

Authors : Najma HAMEED, Khalid SADOZAİ

Pages : 52-58

View : 20 | Download : 14

Publication Date : 2021-04-29

Article Type : Research Paper

Abstract :Objectives: The objective of the study was to reveal the reversal of histo-morphological changes in mice liver induced by combined isoniazid-rifampicin insert ignore into journalissuearticles values(INH-RIF); therapy with sildenafil treatment. Methods: Twenty-one mice weighing between 25–35 g were enrolled in the study. Randomisation was carried out by simple balloting method. The selected mice were sorted into three groups with 7 mice, each group. In group C insert ignore into journalissuearticles values(n=7); control group, mice were administered 0.4ml of saline per kg body weight daily intra peritoneally for 21 days. In group R insert ignore into journalissuearticles values(n=7); INH-RIF group, rifampicin insert ignore into journalissuearticles values(50 mg/kg); and isoniazid insert ignore into journalissuearticles values(50 mg/kg);, dissolved in 4 ml/kg isotonic saline, were administered intra-peritoneally insert ignore into journalissuearticles values(ip); daily for 21 days. In group S insert ignore into journalissuearticles values(n=7); sildenafil administered group, 10 mg/kg sildenafil was given orally by gastric gavage on daily basis along with the intraperitoneal injection of INH-RIF insert ignore into journalissuearticles values(50 mg/kg each); daily for 21 days. Results: Histopathology revealed hepatotoxicity in group R insert ignore into journalissuearticles values(INH-RIF);, while significant improvement was observed in group C insert ignore into journalissuearticles values(INH-RIF-sildenafil);. Conclusion: Sildenafil citrate possesses hepatoprotective role against INH-RIF induced hepatotoxicity.
Keywords : hepatotoxicity, histomorphology, INH RIF, oxidative stress, sildenafil citrate