SYNAPTIC TRANSMISSION: A MODEL ON THE FORMATION OF END-PLATE POTENTIAL AND A STUDY ON SIMULATION

Authors : Levent ÖZBEK, Çağrı TEMUCIN, Bülent CENGIZ, Fikri ÖZTURK

Pages : 24-32

Doi:10.33769/aupse.467095

View : 15 | Download : 7

Publication Date : 2019-06-30

Article Type : Research Paper

Abstract :In this study, the emergences of postsynaptic action potentials are investigated using simulation study which is depended on the statistical model of acetylcholine insert ignore into journalissuearticles values(Ach); quantal release theory at motor end-plate. It is supposed that the end-plate potentials insert ignore into journalissuearticles values(EPP); are sum of miniature end-plate potentials insert ignore into journalissuearticles values(MEPP); which are released as quantal and random in number insert ignore into journalissuearticles values(N);. By the hypothesis that N number has a Poisson and MEPPs have a Gaussian distribution,  EPPs are obtained by simulating distributions parameters. Our study suggests that the simulation of the EPPs are  a convenient tool  in understanding both physiological process of synaptic transmission  and pathological process of neuromuscular junction.  
Keywords : Synaptic transmission, EPP, MEPP