Camellia Sinensis Leaves Hydroalcoholic Extract Improves the Alzheimer’s Disease-Like Alterations Induced by Type 2 Diabetes in Rats

Authors : Muhammet Emin ÇAM, Turgut TAŞKIN

Pages : 93-103

Doi:10.33808/clinexphealthsci.685280

View : 77 | Download : 10

Publication Date : 2020-06-29

Article Type : Research Paper

Abstract :Objective: Novel investigations have confirmed that hyperglycemia is strictly associated with the development of cognitive impairment and dementia. Sodium-dependent glucose transporter insert ignore into journalissuearticles values(SGLT); inhibitors, which are oral antidiabetic drugs, are currently being investigated as the medication in Alzheimer`s disease insert ignore into journalissuearticles values(AD);. In our study, Camellia sinensis insert ignore into journalissuearticles values(green tea);, which inhibits sodium-dependent glucose transporter-1 insert ignore into journalissuearticles values(SGLT-1);, was used in the treatment of type 2 diabetes mellitus insert ignore into journalissuearticles values(T2DM);-induced AD-like alterations via its antidiabetic effects. Methods: High-fat diet/streptozotocin-treated rat model was chosen to provide T2DM-induced AD-like alterations. Antidiabetic effects were evaluated with the measurement of blood glucose level insert ignore into journalissuearticles values(BGL);, oral glucose tolerance test insert ignore into journalissuearticles values(OGTT);, and insulin tolerance test insert ignore into journalissuearticles values(ITT);. On the other hand, novel object recognition test insert ignore into journalissuearticles values(NORT);, open field test insert ignore into journalissuearticles values(OFT);, passive avoidance test insert ignore into journalissuearticles values(PAT);, and Morris’s water maze insert ignore into journalissuearticles values(MWM); test were performed to investigate the anti-Alzheimer`s effects of C. Sinensis. Results: C. sinensis tolerated BGL for a short time but metformin, the first medication prescribed for T2DM, tolerated BGL during the test for 120 min. C. sinensis increased the number of square crosses and the frequency of grooming activity in a similar manner to metformin in OFT. C. sinensis treatment improved exploratory behavior and memory retention components in NORT. The step-through latency decreased in HFD/STZ-treated rat model but it improved with metformin and C. sinensis treatment in PAT. According to the results obtained by the MWM test, C. sinensis treatment slightly improved learning. Conclusion: C. sinensis improved short-term memory and increased the locomotor activity in rats according to the results obtained by NORT, OFT, and PA. 
Keywords : Camillia sinensis, sodium dependent glucose transporter, diabetes mellitus, Alzheimer`s disease, memory

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