The association of ABCC5 and ABCC11 polymorphisms with the pharmacokinetics of 5-FU in advanced gastric cancer patients

Authors : Zeliha PALA KARA, Ezgi OZTAS, Dilek OZTURK, Yasemin AKYEL, Zeynep TURNA, Alper OKYAR, Gül ÖZHAN

Pages : 285-291

Doi:10.33808/clinexphealthsci.757619

View : 24 | Download : 12

Publication Date : 2020-09-29

Article Type : Research Paper

Abstract :Objective: Gastric cancer is the second leading cause of cancer-related death worldwide. 5-Fluorouracil insert ignore into journalissuearticles values(5-FU); is one of the most commonly used drugs to treat cancer, but 5-FU and its forms are characterized by wide inter-individual pharmacokinetic variability. ABCC5 and ABCC11 are members of the ABC transporter superfamily and play a role in the efflux of antineoplastic drugs like 5-FU. Methods: The influence of two SNPs in ABCC5 insert ignore into journalissuearticles values(rs562, T>C); and ABCC11 insert ignore into journalissuearticles values(rs17822931, G>A); was evaluated based on the pharmacokinetics and toxicity of 5-FU in HER2-negative advanced gastric cancer patients treated with cisplatin and 5-FU insert ignore into journalissuearticles values(n=18);. The genetic variants and plasma 5-FU concentrations were detected by RT-PCR and HPLC, respectively. Results: There was no statistically significant difference between 5-FU AUC0-96 h values and ABCC5 insert ignore into journalissuearticles values(rs562; T>C);, 21.04 ±3.46 vs 16.65 μg.h/mL, p=0,261); and ABCC11 insert ignore into journalissuearticles values(rs17822931; G>A);, 17.04 ±4.39 vs 54 ±3.79 mg.h/L, p=0,564); variants. Similarly, there were no statistically significant differences between the variants and the most frequently observed side effects of diarrhea and mucositis. Conclusion: We recommend investigating the noted SNPs more precisely in a larger study population with more comprehensive evaluation.
Keywords : ABCC5, ABCC11, 5 FU, Pharmacogenetics, Gastric cancer