Oxidative Stress in Controlled Hypotension: Assessment with A Novel Oxidative Stress Marker

Authors : Cihan DÖĞER, Ayça Tuba DUMANLI ÖZCAN, Ezgi ERKILIÇ, Süleyman ELLİK, Şemsi Mustafa AKSOY, Murat ALIŞIK, Özcan EREL

Pages : 324-329

Doi:10.33808/clinexphealthsci.798527

View : 23 | Download : 10

Publication Date : 2021-06-30

Article Type : Research Paper

Abstract :Objectives: The aim of this study was to evaluate the effects of oxidative stress on thiol-disulfide homeostasis caused by hypotensive anesthesia in mastoidectomy-tympanoplasty cases undergoing controlled hypotension. Methods: Fifty adult patients scheduled for mastoidectomy and tympanoplasty were included in the study. Anesthesia was induced with lidocaine, propofol, rocuronium, and remifentanil. The maintenance of anesthesia was continued with remifentanil infusion insert ignore into journalissuearticles values(target mean arterial pressure as 60-65 mmHg); along with 2% sevoflurane/40% O2/air mixture. Blood samples were taken 5 times at the t0 insert ignore into journalissuearticles values(before induction);, t1 insert ignore into journalissuearticles values(intraoperatively after intubation);, t2 insert ignore into journalissuearticles values(first hour); and t3 insert ignore into journalissuearticles values(second hour of the operation); and t4 insert ignore into journalissuearticles values(following recovery);. Total thiol insert ignore into journalissuearticles values(TT); and Native Thiol insert ignore into journalissuearticles values(NT); levels were measured, and thus, Di-Sulphide insert ignore into journalissuearticles values(SS);, Di-Sulphide/Native Thiol insert ignore into journalissuearticles values(SSNT);, Di-Sulphide/Total Thiol insert ignore into journalissuearticles values(SSTT);, and Native Thiol/Total Thiol insert ignore into journalissuearticles values(NTTT); values were estimated. Results: During the operation, progressive decrease was observed in thiol levels of patients. There was a significant decrease in t3 thiol values when compared with t0 value. Thiol values were observed to have returned to baseline values after recovery from anesthesia insert ignore into journalissuearticles values(p>0.05);. SS, SSNT and SSTT levels were found as increased in t1 blood samples, but increase in SSNT and SSTT levels was significant. Throughout the operation, values were observed to have dropped and reverted back to initial values. Conclusion: Since the measurement of thiol-disulfide blood values is able to show the instantaneous state of oxidative stress, it can be used in anesthesia practice in which every event occurs very quickly.
Keywords : homeostazis, thioldisülfid, controlled hypotension, oxidative stress