Effect of Non-surgical Periodontal Therapy on Salivary Melatonin Levels

Authors : Kübra KUNDAK, Ayşen YARAT, Başak DOĞAN, Leyla KURU

Pages : 1032-1039

Doi:10.33808/clinexphealthsci.1053211

View : 18 | Download : 4

Publication Date : 2022-12-30

Article Type : Research Paper

Abstract :Objective: Melatonin, a hormone secreted predominantly by pineal gland in a circadian manner, has antioxidant and anti-inflammatory effects. The current research is conducted to explore the influence of non-surgical periodontal therapy insert ignore into journalissuearticles values(NSPT); on levels of salivary melatonin in subjects with gingivitis and periodontitis. Methods: Sixty systemically healthy participants were included in this study; the groups are as follows: gingivitis insert ignore into journalissuearticles values(G);, chronic periodontitis insert ignore into journalissuearticles values(CP);, generalized aggressive periodontitis insert ignore into journalissuearticles values(GAP); and periodontally healthy insert ignore into journalissuearticles values(H);. NSPT was applied to G group patients for 2 sessions, to CP and GAP group patients for 4 sessions. Plaque and gingival indices, probing depth insert ignore into journalissuearticles values(PD);, bleeding on probing insert ignore into journalissuearticles values(BOP);, and clinical attachment level insert ignore into journalissuearticles values(CAL); were documented at baseline and 3 months post – treatment and early morning salivary samples were collected. ELISA was used to detect melatonin levels in saliva. Pittsburgh Sleep Quality Index insert ignore into journalissuearticles values(PSQI); questionnaire was performed to evaluate of sleep quality of patients. Results: At baseline, significant difference in gingival index, PD, BOP and CAL values was detected among all groups insert ignore into journalissuearticles values(p 0.05);, a significant elevation in the level of salivary melatonin was found only in the G group after NSPT insert ignore into journalissuearticles values(p<0.05);. PSQI scores differed significantly among groups insert ignore into journalissuearticles values(p<0.05);. Conclusion: The salivary melatonin levels in the presence of gingivitis and periodontitis varied at baseline and elevated following NSPT parallel to the improvement in clinical parameters.
Keywords : Melatonin, gingivitis, periodontitis