Monocyte to HDL Ratio in Preeclamptic Patients: Can It Be a Predictive Marker?

Authors : Şule YILDIRIM KÖPÜK, Nida NACİ, Canan ÖZCAN, İpek ULU

Pages : 835-839

Doi:10.33808/clinexphealthsci.1094774

View : 27 | Download : 7

Publication Date : 2022-12-30

Article Type : Research Paper

Abstract :Objective: Preeclampsia insert ignore into journalissuearticles values(PE); is a severe and high – risk pregnancy complication for both the mother and fetus. Generalized inflammation is a prominent feature of PE. Based on the proinflammatory property of monocytes and the contrary anti-inflammatory mechanism of High-density lipoprotein insert ignore into journalissuearticles values(HDL);, monocyte count to HDL ratio insert ignore into journalissuearticles values(MHR); could be used as a new marker of systemic inflammation. Our aim is to evaluate the relationship between PE and MHR in terms of diagnosis of PE. Methods: A retrospective case-control study was recruited preeclamptic and healthy pregnant women in the third trimester of gestation insert ignore into journalissuearticles values(n=69 and n= 71, respectively);. Results: Maternal age insert ignore into journalissuearticles values(years);, gravity, and body mass index insert ignore into journalissuearticles values(BMI); were similar in the two groups. The gestational week at delivery was significantly earlier in the PE group than in the control group insert ignore into journalissuearticles values(p < 0.001);. Fetal weight in PE was significantly lower than in the control group insert ignore into journalissuearticles values(p = 0.001);. Monocyte counts were comparable between the two groups insert ignore into journalissuearticles values(0.76 ± 0.28 vs. 0.76 ± 0.71; p = 0.25);. The mean HDL level of PE patients was lower than the control group, but it was not statistically significant insert ignore into journalissuearticles values(63.87 ± 15.3 vs. 68.23 ± 13.5; p = 0.77);. The monocyte/HDL ratio was higher in the PE group, but this increment did not reach statistical significance insert ignore into journalissuearticles values(12.5 ± 5.9 vs. 10.9 ± 4.3, p = 0.08);. Conclusion: MHR might be a new marker of inflammation and oxidative stress. The present study did not reach a result indicating a diagnostic marker of PE. Further studies with more cases are needed to evaluate the relationship between MHR and PE.
Keywords : preeclampsia, monocyte, HDL, MHR, marker