Clinical and Biochemical Effects of Smoking on Non-Surgical Periodontal Treatment in Grade III Stage C Periodontitis Patients

Authors : Volkan ARIKAN, Nimet Gül GÖRGÜLÜ, Başak DOĞAN

Pages : 218-227

Doi:10.33808/clinexphealthsci.1128101

View : 34 | Download : 13

Publication Date : 2023-03-28

Article Type : Research Paper

Abstract :Objective: The purpose of this study was to evaluate the effect of smoking on clinical parameters and the serum and saliva levels of RANKL, OPG, and IL-34 in periodontitis stage III grade C insert ignore into journalissuearticles values(III-C); patients after non-surgical periodontal treatment insert ignore into journalissuearticles values(NSPT);. Methods: A total of 60 subjects, 40 periodontitis-III-C patients insert ignore into journalissuearticles values(20 smokers and 20 non-smokers); and 20 non-smoker periodontally healthy individuals, were included. All clinical periodontal parameters were recorded, and unstimulated saliva and serum samples were collected from all patients at baseline, but at 1 and 3 months only from periodontitis patients insert ignore into journalissuearticles values(N=40);. Saliva and serum levels of RANKL, OPG, and IL-34 were analyzed by ELISA. Results: At baseline only whole mouth probing depth insert ignore into journalissuearticles values(PD); and percent of sites with PD>5mm were higher in smokers than non-smoker periodontitis patients insert ignore into journalissuearticles values(p .05);. Only saliva IL-34 levels were higher in all-periodontitis patients than healthy individuals insert ignore into journalissuearticles values(p=.001); and decreased in both periodontitis groups after NSPT insert ignore into journalissuearticles values(p<.05);. Moreover, elevated serum RANKL level was detected in smokers compared to nonsmoker periodontitis or healthy ones at baseline insert ignore into journalissuearticles values(p<.05);. Serum RANKL levels exhibited no change after NSPT in either periodontitis groups. Conclusions: The smokers are less responsive to NSPT, and saliva IL-34 can be a potential inflammatory marker of periodontitis-III-C. Moreover, high serum RANKL levels are associated with smoking.
Keywords : periodontitis, smoking, interleukin 34, receptor activator of nuclear factor kappa B ligand, osteoprotegerin