COBALT AND ASCORBIC ACID TREATMENT: EFFECTS ON TISSUE NITRIC OXIDE LEVELS IN STREPTOZOTOCIN- DIABETIC RAT

Authors : Özlem YILDIRIM

Pages : 1-14

View : 11 | Download : 7

Publication Date : 2010-06-01

Article Type : Research Paper

Abstract :The aim of present study was to determine the effect of cobalt insert ignore into journalissuearticles values(II); chloride insert ignore into journalissuearticles values(CoCl2); and CoCl2plus ascorbic acid insert ignore into journalissuearticles values(AA); on liver and kidney nitric oxide level at different stage of diabetes. Three days after streptozotocin insert ignore into journalissuearticles values(STZ); injection, rats were divided into six groups: control, diabetic, control and diabetic treated with cobalt chloride, control and diabetics treated with cobalt chloride plus ascorbic acid. 0.5 mM CoCl2 or 0.5 mM CoCl2 plus 1 g/l ascorbic acid were added to their drinking water daily. At the end of the second, fourth and sixth week of the treatment all animals were sacrified by decapitation. Liver and kidney tissues were removed for the determination of nitric oxide insert ignore into journalissuearticles values(NO); levels. Cobalt treatment effectively decreased the nitric oxide levels both in liver and kidney tissues of diabetic rats. Thus, the effect of oral administration of cobalt treatment may prove effective in improving the impaired nitrite status during the early stage of diabetes and ascorbic acid supplementation at this dose insert ignore into journalissuearticles values(1g/l); potentiates the effectiveness of cobalt action
Keywords : Nitric oxide, diabetes, cobalt, ascorbic acid, liver and kidney