BIOAPYGIN HERBAL OINTMENT AND PESSARIES COMPARED TO ACIDOSALUS PESSARIES AND VAGINAL PROBIOTIC IN THE TREATMENT OF VULVO-VAGINAL DISORDERS

Authors : Višnja OREŠČANİN, štefica FİNDRİ GUŠTEK

Pages : 11-22

Doi:10.38093/cupmap.552083

View : 21 | Download : 31

Publication Date : 2019-07-29

Article Type : Research Paper

Abstract :Objective / Purpose : The objective of the study was assessment of the clinical efficacy and safety of Bioapigyn Ò vaginal ointment and pessaries compared to Acidosalus Ò pessaries and vaginal probiotic in alleviating vulvo-vaginal disorders. Materials and methods : 124 females were randomly selected into four groups insert ignore into journalissuearticles values(each of 31 participants); and treated once a day for ten days with: A); Bioapigyn Ò vaginal pessaries insert ignore into journalissuearticles values(one pessary per day);; B); 2.5 mL of Bioapygin Ò vaginal ointment; C); Acidosalus Ò vaginal pessaries insert ignore into journalissuearticles values(one pessary per day);; D); 2.5 mL of Acidosalus Ò vaginal probiotic. All the patients were subjected to gynecological examination, measurement of vaginal pH, Pap test, native and KOH test, self-assessment and clinical assessment of the symptoms at baseline and following the therapy. Results : Following the treatment with Bioapigin Ò vaginal ointment, Bioapigyn Ò pessaries, Acidosalus Ò pessaries, Acidosalus Ò vaginal probiotic the total score of vulvo-vaginal disorders decreased for 85.2%, 88.9%, 82.7% and 78%, respectively and vaginal pH decreased between 9.1% and 14.3%. Native test showed normalization of the vaginal flora following the treatment with all four products with no significant difference among the products. Conclusion/Discussion : Both Bioapigyn Ò and Acidosalus Ò products were highly efficient in alleviation of vulvo-vaginal disorders. The products created unfavorable conditions for pathogenic growth through the lowering of vaginal pH value, promoting the growth of lactobacilli, creating the environment with low water activity and creating a protective layer on the damaged mucosa that creates a physical barrier to the entrance of the pathogens into the cells and enables the recovery of the vaginal mucosa.
Keywords : Bioapygin, Acidosalus, vulvo vaginal disorders, vaginal pH, herbal macerates