Effect of a tropical plant (Hunteria umbellata) in the management of Streptozotocin induced Diabetes Mellitus and other physiological and biochemical functions in Wistar

Authors : Fidelis OKOLAFOR, Frederick EKHAISE

Pages : 1-12

Doi:10.38093/cupmap.842583

View : 20 | Download : 11

Publication Date : 2021-05-02

Article Type : Research Paper

Abstract :The antidiabetic effect of Hunteria umbellata extracts insert ignore into journalissuearticles values(aqueous and methanol); on hematological, lipid profile and biochemical parameters in streptozotocin-induced diabetes in female wistar rats was studied. The phytochemical screening of the seed extracts was determined using standard chemical methods. Twenty five insert ignore into journalissuearticles values(25); wistar rats weighing between 117g and 170g were shared into five insert ignore into journalissuearticles values(5); groups of five animals per group for the physiological studies. All treatment groups were administered 500 mg/kg per body weight of H. umbellata extracts. Group 1: normal control, group 2: negative or diabetic control, group 3: metformin + streptozotocin insert ignore into journalissuearticles values(STZ);, group 4: aqueous extract of H. umbellata + STZ and group 5: methanol extract of H. umbellata + STZ. Diabetes was induced with 55mg/kg body weight streptozotocin insert ignore into journalissuearticles values(STZ);. Quantitative phytochemical screening of aqueous and methanol seed extracts of H. umbellata reviewed the presence of secondary metabolites such as, saponins, phytate, oxalate, anthraquinones, Cyanogenic glycoside; where phenols and alkaloids recorded highest concentrations in both extracts. The hypoglycaemic studies of methanol extract revealed significant insert ignore into journalissuearticles values(p<0.005); reduction on the fasting blood glucose levels of experimental animals for group 5 compared to moderate reduction in group 3. Group 4 recorded increase in the blood glucose levels of wistar rats. The haematological parameters were not significant insert ignore into journalissuearticles values(p>0.05); for all treatment groups. Group 5 recorded significance insert ignore into journalissuearticles values(p<0.05); amount of high density lipoproteins insert ignore into journalissuearticles values(HDL);, total cholesterol insert ignore into journalissuearticles values(CHOL);, triglyceride insert ignore into journalissuearticles values(TRIG); and low density lipoproteins insert ignore into journalissuearticles values(LDL); while CHOL was significant insert ignore into journalissuearticles values(p<0.05); for group 3. The biochemical parameters were within safe limit. The methanol extract of H. umbellata possesses the potentials for the managements of blood glucose levels compared to conventional drug insert ignore into journalissuearticles values(metformin);.
Keywords : Antidiabetic, Phytochemical screening, Streptozotocin, wistar rats, Hunteria umbellata, Meforming