In-vitro comparison release study of novel liposome and conventional formulation containing Rosmarinus officinalis extract

Authors : İsmail ASLAN, Ahmet Arif KURT

Pages : 13-21

Doi:10.38093/cupmap.848115

View : 18 | Download : 8

Publication Date : 2021-05-02

Article Type : Research Paper

Abstract :The aim of this research study was to examine the effect of conventional Rosmarinus officinalis insert ignore into journalissuearticles values(without delivery systems); extract and liposomal delivery system incorporated extract on skin permeation velocity in vitro conditions was to determine whether there was a significant difference insert ignore into journalissuearticles values(in terms of duration); over the determined parameters. 47 mm diameter with a capacity of 20 ml in a water bath applied to the membrane surface in 37 ° C environment and using a double walled franz diffusion cell containing a polycarbonate membrane filter. 1.3.5.10. 20.40. in minutes and upto 160 minutes 50 rpm rotation speed insert ignore into journalissuearticles values(imitating skin application speed); with classical methods and delivery named by calculating the transition rates of Rosmarinus officinalis extracts obtained by the alternative method through the diffusion cell. As a result of the study, it was clearly determined that the mixture of rosemary insert ignore into journalissuearticles values(Rosmarinus officinalis); extract in the liposomal carrier system at a volume ratio of 1: 1 compared with the conventional formula has a very high in vitro release rate of 160 minutes, even absorbed within minutes.
Keywords : Phytochemicals, Herbal liposomes, Rosmarinus officinalis, In vitro release, Franz diffusion cell