Antibacterial Amphiphilic Composities of Poly(Diethylamino Eethyl Methacrylate-co-Ethyl Methacrylate)/Polyindole Controlling Biofilm Adhesion for Antifouling Investigations

Authors : Cengiz Soykan, Burak Tüfekçi

Pages : 167-175

View : 16 | Download : 11

Publication Date : 2025-05-01

Article Type : Research Paper

Abstract :Amphiphilic and conductive composites are considered notable biomaterials and used as antibacterial agents because they effectively inhibit bacterial growth. In the current study; In the first stage, amphiphilic poly(DEAEMA-co-EMA) copolymers were synthesized from the hydrophilic monomer 2-diethylamino ethylmethacrylate (DEAEMA) and the hydrophobic monomer ethyl methacrylate (EMA) using free radical polymerization. In the second stage, five series composites were prepared at different concentrations using indole conductive monomer in the presence of iron(III) chloride (FeCl3) using the in situ oxidative polymerization technique in poly(DEAEMA-co-EMA) copolymer. The structures of the polymer composites (PCs) were elucidated using FTIR, TGA, SEM, AFM characterization techniques. PCs exhibited significant performance on bacterial biofilm adhesion tested using the Streptococcus mutans by the test tube method (TM). In this study, the 0.006 mg/ml concentration of PC1 reduced the biofilm formation of Streptococcus mutans by 83.199%; PC5, 89.218%; PC3 inhibited 86.078%. 0.003 mg/ml concentration of PC1 prevented S. mutans from forming biofilm by 47.055%; PC5, 71.285%; PC3 was found to inhibit 68.139%. As the concentration and amounth of poly(indole) in the CPs increases, the % antibiofilm effect also increases. From these results, it can be said that PCs as biofilms may be useful materials in antifouling research.
Keywords : Poly(Diethylamino ethyl methacrylate-co-ethyl methacrylate), Polyindole, Antifouling, Streptococcus mutans, Biofilm