Is There A Genetic Predisposition for Transitional Cell Carcinoma of the Bladder at a Young Age?

Authors : Selim TAŞ, Ali Erhan EREN, Mahmut Taha ÖLÇÜCÜ, Barış PAKSOY, Ekrem İSLAMOĞLU, Mehmet Salih BOĞA

Pages : 102-108

Doi:10.54233/endouroloji.20231503-1342430

View : 31 | Download : 34

Publication Date : 2023-09-30

Article Type : Research Paper

Abstract :Objective: The aim of this study is to determine whether there is a genetic predisposition in young patients with transitional cell carcinoma insert ignore into journalissuearticles values(TCC); of the bladder. Material And Methods: Data were collected from a total of 652 patients who underwent transurethral resection of bladder tumor insert ignore into journalissuearticles values(TUR-BT); between January 2010 and January 2021. Seven patients under the age of 40, non-smokers, and without occupational predisposing factors to urinary tract TCC were included in the study. Age, body mass index insert ignore into journalissuearticles values(BMI);, sex, occupation, and five-year follow-up were collected retrospectively. A total of 403 cancer-related genes were analyzed from the patients’ blood samples. The Clinical Exome Sequencing test was used to identify genetic mutations. Results: Six of the patients were male and one patient was female. The mean age and BMI were 31.42 ± 2.12 insert ignore into journalissuearticles values(22-39); years and 21.72 ± 33.14 insert ignore into journalissuearticles values(22-27.7); kg/m2, respectively. None of the patients had a first-degree relative with urinary tract TCC. Of all the patients, only one patient had a deletion of exons 1 to 17 in the breakpoint cluster region gene. Conclusion: Genetic predisposing factors in young bladder TCC have not been clearly identified. Although our study included a limited number of patients, our results showed no genetic predisposition in young patients with bladder TCC without family history of bladder cancer. To evaluate the exact relationship, prospective randomised controlled trials with larger numbers of patients are needed.
Keywords : Mesane Kanseri, gen değişimleri, transizyonel hücreli karsinom, genç hasta