The Relationship Between Urinary System Stone Disease and Serum Fetuin-A Glycoprotein

Authors : Abdulmecit Yavuz, Serdar Arısan

Pages : 71-77

Doi:10.54233/endourolbull-1621723

View : 18 | Download : 19

Publication Date : 2025-05-30

Article Type : Research Paper

Abstract :Objective: This study aimed to investigate the relationship between Fetuin-A glycoprotein, a known systemic and localized calcification inhibitor, and urinary system stone disease.  Material and Methods: A total of 63 patients with urinary stone disease and 70 healthy controls were included. Serum Fetuin-A levels were measured using enzyme-linked immunosorbent assay, and various biochemical parameters were analyzed. Statistical comparisons were performed by using Pearson correlation to determine relationships, with significance set at p<0.05.  Results: The mean serum Fetuin-A levels were slightly higher in the stone disease group (503.5 ± 87.6 mg/dL) compared to the control group (462.7 ± 101.6 mg/dL); however, the difference was not statistically significant (p>0.05). The mean age was 42.87 ± 11.0 years in the stone group and 41.6 ± 11.7 years in the control group (p=0.497). In the stone group, 65% were male and 35% female, while in the control group, 66% were male and 34% female, with no significant difference in gender distribution (p=0.831). Body mass index (BMI) was 25.3 ± 2.57 kg/m² in the stone group and 26.9 ± 3.08 kg/m² in the control group, also showing no significant difference (p=0.067). No correlations were found between serum Fetuin-A levels and other parameters such as age, BMI, or biochemical markers.  Conclusion: Although some previous studies have suggested a relationship between Fetuin-A levels and urinary stone disease, this study found no significant association. Further research focusing on genetic polymorphisms of Fetuin-A may clarify its role in stone formation.
Keywords : böbrek taşı, Üriner taş, fetuin

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