Fetal Hand Anomalies: 18 Cases Diagnosed Between 2020-2022 from a Single Tertiary Care Center

Authors : Ayça Dilruba ASLANGER, Tugba KALAYCİ, Tuğba SARAÇ SİVRİKOZ, Seher BAŞARAN, Oya UYGUNER

Pages : 149-154

Doi:10.26650/experimed.1188882

View : 33 | Download : 14

Publication Date : 2022-12-31

Article Type : Research Paper

Abstract :Objective: The aim of this study was to present and investigate fetal cases with hand anomalies by discussing their antenatal and postmortem findings. Materials and Methods: This retrospective review re-evaluates fetal cases identified antenatally with hand anomalies including polydactyly, syndactyly, reduction defects, and oligodactyly. The following data were collected from the patients’ medical records: Demographic information, family histories, X-ray images, photographs, and cytogenetic/molecular findings. The study also performed a chromosome analysis, array-comparative genomic hybridization insert ignore into journalissuearticles values(CGH);, and Sanger sequencing of FGFR2 and GLI3 genes. Results: This study involved 18 cases with hand anomalies, all of which were diagnosed antenatally. Three cases were diagnosed with Greig cephalopolysyndactyly, Apert Syndrome, and triploidy, respectively. Conclusions: Fetal ultrasonography is the most valuable tool for providing prenatal diagnosis. Prenatal detection of hand anomalies causes great anxiety for parents; therefore, making an accurate diagnosis list is important for the prenatal period. Prenatal diagnosis and management of hand anomalies must involve a multidisciplinary team composed of a perinatologist, a clinical geneticist, and a hand surgeon.
Keywords : Polydactyly, syndactyly, prenatal diagnosis

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